Phosphoramide mustard
| CAS No. | 10159-53-2 | Cat. No. | BCP48451 |
| Name | Phosphoramide mustard | ||
| Synonyms | Friedman acid;Phosphorodiamidic mustard; | ||
| Formula | C4H11Cl2N2O2P | M. Wt | 221.02 |
| Description | Phosphoramide Mustard is one of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide. Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA Alkylator/Crosslinker | ||
Structure
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