T2AA
| CAS No. | 1380782-27-3 | Cat. No. | BCP48541 |
| Name | T2AA | ||
| Synonyms | |||
| Formula | C15H15I2NO3 | M. Wt | 511.09 |
| Description | T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor. T2AA inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM), leading to the suppression of DNA replication stress by stalling DNA replication forks. T2AA inhibits the interaction of PCNA with DNA polymerase δ and arrests cell growth in S-phase. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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