西拉普利一水化合物
| CAS号 | 92077-78-6 | 货号 | BCP48662 |
| 中文名 | 西拉普利一水化合物 | ||
| 英文名 | Cilazapril monohydrate | ||
| 中文别名 | 西拉普利水合物; | ||
| 英文别名 | Ro 31-2848 monohydrate; | ||
| 分子式 | C22H33N3O6 | 分子量 | 435.52 |
| 生物活性 | Cilazapril Monohydrate is a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. | ||
| 信号通路 | Protease/Metabolic Enzyme Hormone Pathay | ||
| 靶 点 | RAAS/ACE | ||
结构式
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