RA-9
CAS No. | 919091-63-7 | Cat. No. | BCP48946 |
Name | RA-9 | ||
Synonyms | RA 9; RA9; RA-9 UPS inhibitor; | ||
Formula | C19H15N3O5 | M. Wt | 365.34 |
Description | RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells. | ||
Pathways | Cell Cycle/DNA Damage | ||
Targets | DUB |
Structure
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