RA-9

  • Chemical Properties
CAS No. 919091-63-7 Cat. No. BCP48946
Name RA-9
Synonyms RA 9; RA9; RA-9 UPS inhibitor;
Formula C19H15N3O5 M. Wt 365.34
  • Biological Activity
Description RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells.
Pathways Cell Cycle/DNA Damage 
Targets DUB 

Structure

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