EMI1
| CAS No. | 35773-42-3 | Cat. No. | BCP49115 |
| Name | EMI1 | ||
| Synonyms | EMI 1;EMI-1;EGFR MamTH Inhibitor 1; | ||
| Formula | C20H18N2O3 | M. Wt | 334.37 |
| Description | EMI1 is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. Additionally, EMI1 potently depolymerized interphase microtubules, disrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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