Tuspetinib hydrate
| CAS No. | 2758339-04-5 | Cat. No. | BCP49212 |
| Name | Tuspetinib hydrate | ||
| Synonyms | HM43239 monohydrate;HM-43239 monohydrate;HM 43239 monohydrate; | ||
| Formula | C29H35ClN6O | M. Wt | 519.1 |
| Description | Tuspetinib is a selective, reversible type I inhibitor of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) with potential antineoplastic activity. Upon administration, tuspetinib reversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FLT3 | ||
Structure
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