Dextromethadone
| CAS号 | 5653-80-5 | 货号 | BCP49227 |
| 中文名 | Dextromethadone | ||
| 英文名 | Dextromethadone | ||
| 中文别名 | |||
| 英文别名 | Esmethadone;S-Methadone; | ||
| 分子式 | C21H27NO | 分子量 | 309.4 |
| 生物活性 | Dextromethadone is a 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. It has a role as a NMDA receptor antagonist and an opioid analgesic. It is an enantiomer of a levomethadone. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | AMPA/NMDA | ||
结构式
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