BI-2865
| CAS No. | 2937327-93-8 | Cat. No. | BCP49601 |
| Name | BI-2865 | ||
| Synonyms | BI 2865;BI2865; | ||
| Formula | C23H27N7O2S | M. Wt | 465.57 |
| Description | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM). | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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