BI-0474
| CAS No. | 2750570-55-7 | Cat. No. | BCP49602 |
| Name | BI-0474 | ||
| Synonyms | BI0474;BI 0474; | ||
| Formula | C30H37N9O2S | M. Wt | 587.74 |
| Description | BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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