CMP-5 dihydrochloride
| CAS No. | 2309409-79-6 | Cat. No. | BCP49698 |
| Name | CMP-5 dihydrochloride | ||
| Synonyms | CMP-5 2HCl; | ||
| Formula | C21H23Cl2N3 | M. Wt | 388.3 |
| Description | CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase | ||
Structure
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