PTP CD45 Inhibitor
| CAS No. | 345630-40-2 | Cat. No. | BCP08444 |
| Name | PTP CD45 Inhibitor | ||
| Synonyms | SF1670;PTEN inhibitor;SF 1670;SF-1670; | ||
| Formula | C19H17NO3 | M. Wt | 307.3 |
| Description | SF1670 is an inhibitor of PTEN (IC50 = 2 μM). PTEN (Phosphatase and Tensin Homolog deleted on Chromosome 10) is a 3’ phosphoinositide phosphatase that converts PI(3,4,5)P3 to PI(4,5)P2 thus opposing PKB/Akt activation by PI 3-K. Pretreatment of neutrophils with SF1670 leads to enhanced fMLP-1 induced PI(3,4,5)P3 signaling effects such as Akt phosphorylation, NADPH oxidase-mediated superoxide formation, cell polarization, chemotactic migration, and phagocytosis. SF1670 also inhibits CD45 (IC50 | ||
| Pathways | Protease/Metabolic Enzyme PI3K/Akt/mTOR | ||
| Targets | Phosphatase PTEN | ||
Structure
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