TAK-441
| CAS No. | 1186231-83-3 | Cat. No. | BCP20946 |
| Name | TAK-441 | ||
| Synonyms | LM2094; TAK441; TAK 441; | ||
| Formula | C28H31F3N4O6 | M. Wt | 576.56 |
| Description | TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway. TAK-441 showed activity to suppress transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibited tumor growth (treatment/control ratio, 3%) in a mouse medulloblastoma allograft model owing to the improved PK profile based on increased solubility. TAK-441 is currently in clinical trials for the treatment of advanced solid tumors. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Hedgehog | ||
Structure
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