ZCL 278
| CAS No. | 587841-73-4 | Cat. No. | BCP08398 |
| Name | ZCL 278 | ||
| Synonyms | ZCL278;ZCL-278; | ||
| Formula | C21H19BrClN5O4S2 | M. Wt | 584.89 |
| Description | ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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