HBX 41108
| CAS No. | 924296-39-9 | Cat. No. | BCP08394 |
| Name | HBX 41108 | ||
| Synonyms | HBX41108; HBX-41108; HBX 41,108; HBX-41,108; HBX41,108; | ||
| Formula | C13H3ClN4O | M. Wt | 266.64 |
| Description | HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DUB | ||
Structure
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