C646
| CAS No. | 328968-36-1 | Cat. No. | BCP08378 |
| Name | C646 | ||
| Synonyms | C 646;C-646; | ||
| Formula | C24H19N3O6 | M. Wt | 445.42 |
| Description | C646 is a potent histone acetyltransferase p300 inhibitor. C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. C646 radiosensitizes lung cancer cells by enhancing mitotic catastrophe. C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Note: this molecule exists as a mixture of cis- and trans- isomers. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Acetyltransferase | ||
Structure
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