Rigosertib

CAS No.	592542-59-1	Cat. No.	BCP08296
Name	Rigosertib
Synonyms	Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phenyl]-;
Formula	C21H24NNaO8S	M. Wt	473.43

Description	PI3K signaling promotes the growth and survival of cells under stressful conditions, such as under low oxygen levels that are often found in tumors. If the PI3K pathway is over-active, apoptosis of cancer cells is diminished, leading to excessive cellular growth. By inhibiting the PI3K pathway, rigosertib promotes tumor cell apoptosis. Rigosertib also influences signals along the PI3K pathway, such as those leading to the production of cyclin D1.
Pathways	Cell Cycle/DNA Damage
Targets	PLK

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