Rigosertib
| CAS号 | 592542-59-1 | 货号 | BCP08296 |
| 中文名 | Rigosertib | ||
| 英文名 | Rigosertib | ||
| 中文别名 | |||
| 英文别名 | Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phenyl]-; | ||
| 分子式 | C21H24NNaO8S | 分子量 | 473.43 |
| 生物活性 | PI3K signaling promotes the growth and survival of cells under stressful conditions, such as under low oxygen levels that are often found in tumors. If the PI3K pathway is over-active, apoptosis of cancer cells is diminished, leading to excessive cellular growth. By inhibiting the PI3K pathway, rigosertib promotes tumor cell apoptosis. Rigosertib also influences signals along the PI3K pathway, such as those leading to the production of cyclin D1. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PLK | ||
结构式
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