RI-1
| CAS No. | 415713-60-9 | Cat. No. | BCP08293 |
| Name | RI-1 | ||
| Synonyms | RAD51 inhibitor RI-1;RAD51 inhibitor 1;RI 1; | ||
| Formula | C14H11Cl3N2O3 | M. Wt | 361.61 |
| Description | RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | RAD51 | ||
Structure
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