Norharmane
| CAS号 | 244-63-3 | 货号 | BCP20998 |
| 中文名 | Norharmane | ||
| 英文名 | Norharmane | ||
| 中文别名 | |||
| 英文别名 | β-Carboline; 2-Azacarbazole; | ||
| 分子式 | C11H8N2 | 分子量 | 168.07 |
| 生物活性 | Norharmane is a β-Carboline alkaloid that is widespread in plants and animals, and frequently act as benzodiazepine inverse agonists. Norharmane showed a potent inhibition against α-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively. A Lineweaver-Burk plot revealed that norharman inhibited α-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | IDO | ||
结构式
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