Streptozocin

CAS No.	18883-66-4	Cat. No.	BCP08218
Name	Streptozocin
Synonyms	U9889; U-9889; U 9889; NCI-C03167; NSC-85998; AI3-50821; NRRL 2697; STZ; SZC; SZN;
Formula	C8H15N3O7	M. Wt	265.22

Description	Streptozocin is a methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression.
Pathways	Cell Cycle/DNA Damage
Targets	DNA Alkylator/Crosslinker

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