b-AP15
| CAS No. | 1009817-63-3 | Cat. No. | BCP08149 |
| Name | b-AP15 | ||
| Synonyms | LM 3077;LM3077;b-AP-15;NSC 687852;NSC-687852;NSC687852; | ||
| Formula | C22H17N3O6 | M. Wt | 419.39 |
| Description | b-AP15 is a novel inhibitor of proteasome deubiquitination. b-AP15 displays antitumor activity in several preclinical, solid tumor models. b-AP15 triggers time- and dose-dependent apoptosis of the human multiple myeloma (MM) cell lines RPMI8226 and U266, as determined by phosphatidylserine exposure. Furthermore, b-AP15 triggered processing of pro-caspase-3 and cleavage of poly (ADP-ribose) polymerase in MM cells. b-AP15 also induced caspase-independent apoptosis in primary human natural killer cells. b-AP15 may have potential for treatment of multiple myeloma patients. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DUB | ||
Structure
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