PF-04880594
  • 化学数据
CAS号 1111636-35-1 货号 BCP21016
中文名 PF-04880594
英文名 PF-04880594
中文别名
英文别名 PF04880594; PF 04880594;
分子式 C19H16F2N8 分子量 394.38
  • 用途
生物活性 PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. The combination treatment with PF-04880594 and MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers.
信号通路 MAPK Pathway 
靶 点 Raf 

结构式

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