ETP-46464
| CAS No. | 1345675-02-6 | Cat. No. | BCP08061 |
| Name | ETP-46464 | ||
| Synonyms | ETP 46464; ETP46464; | ||
| Formula | C30H22N4O2 | M. Wt | 470.52 |
| Description | ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50 = 0.6, 14, 36, 170, and 545 nM, respectively) and preferentially suppresses radiation-induced cellular ATR activity (>90% at 500 nM) over ATM or DNA-PK activity (IC50 > 5 uM) in | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | ATM/ATR mTOR | ||
Structure
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