NSC 405020
| CAS No. | 7497-07-6 | Cat. No. | BCP08049 |
| Name | NSC 405020 | ||
| Synonyms | NSC-405020; NSC405020; | ||
| Formula | C12H15Cl2NO | M. Wt | 260.16 |
| Description | Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | MMP | ||
Structure
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