AG-1478
| CAS No. | 175178-82-2 | Cat. No. | BCP07988 |
| Name | AG-1478 | ||
| Synonyms | AG1478; Tyrphostin AG1478; Tyrphostin AG-1478; Tyrphostin AG 1478; Tyrphostin AG1478; | ||
| Formula | C16H14ClN3O2 | M. Wt | 315.75 |
| Description | Tyrphostin AG 1478 has been demonstrated to be a selecetive and potent inhibitor of EGFR (Epidermal Growth Factor Receptor ) in a variety of cell lines. In Rat-1 fibroblasts, Tyrphostin AG 1478 was demonstrated to downregulate EGF-stimulated DNA synthesis. The induction of p21/ip1/WAF1 and activation of EGF-dependent src-family kinase was noted to be blocked by Tyrphostin AG 1478 in the epidermoid carcinoma cell line A431. Additionally, a study utilizing early-weaned rats to study EGFR signaling | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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