Way255348
| CAS No. | 872141-23-6 | Cat. No. | BCP21063 |
| Name | Way255348 | ||
| Synonyms | WAY-255348; WAY 255348; | ||
| Formula | C16H14FN3O | M. Wt | 283.3 |
| Description | WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways. | ||
| Pathways | Hormone Pathay | ||
| Targets | Progesterone Receptor | ||
Structure
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