Aclarubicin Hydrochloride

CAS No.	75443-99-1	Cat. No.	BCP07926
Name	Aclarubicin Hydrochloride
Synonyms	Aclacinomycin A hydrochloride; Aclarubicin HCl; Antibiotic MA144A1;MA-144A1;MA144A1;MA 144A1;
Formula	C42H54ClNO15	M. Wt	848.34

Description	Aclarubicin hydrochloride is an anthracycline produced by Streptomyces galilaeus. Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.
Pathways	Cell Cycle/DNA Damage
Targets	Topoisomerase

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