EPZ005687
| CAS No. | 1396772-26-1 | Cat. No. | BCP07899 |
| Name | EPZ005687 | ||
| Synonyms | EPZ 005687; EPZ-005687; | ||
| Formula | C32H37N5O3 | M. Wt | 539.67 |
| Description | EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2) and is involved in repressing gene expression through methylation of histone H3 on lysine 27 (H3K27). EZH2 overexpression is implicated in tumorigenesis and correlates with poor prognosis in several tumour types. EPZ005687, a potent inhibitor of EZH2 (K(i) of 24 nM). EPZ005687 reduces H3K27 methylation in various lymphoma cells; this translates into apoptotic cell killing in heterozygous Tyr641 or Ala677 mutant cells, with | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase Epigenetic Reader Domain | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.