Ixabepilone

  • Chemical Properties
CAS No. 219989-84-1 Cat. No. BCP07847
Name Ixabepilone
Synonyms Azaepothilone B;BMS247550;BMS-247550;Ixempra;BMS 247550;; BMS 247550-1;BMS-247550-1;BMS247550-1;
Formula C27H42N2O5S M. Wt 506.7
  • Biological Activity
Description Ixabepilone is an orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.
Pathways Cell Cycle/DNA Damage 
Targets Microtubule 

Structure

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