Ixabepilone
CAS No. | 219989-84-1 | Cat. No. | BCP07847 |
Name | Ixabepilone | ||
Synonyms | Azaepothilone B;BMS247550;BMS-247550;Ixempra;BMS 247550;; BMS 247550-1;BMS-247550-1;BMS247550-1; | ||
Formula | C27H42N2O5S | M. Wt | 506.7 |
Description | Ixabepilone is an orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. | ||
Pathways | Cell Cycle/DNA Damage | ||
Targets | Microtubule |
Structure
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