StemRegenin 1
| CAS No. | 1227633-49-9 | Cat. No. | BCP07738 |
| Name | StemRegenin 1 | ||
| Synonyms | StemRegenin1;SR-1;SR1;SR 1; | ||
| Formula | C24H23N5OS | M. Wt | 429.54 |
| Description | The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor.SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells. | ||
| Pathways | Others Pathway | ||
| Targets | AhR | ||
Structure
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