Cidofovir dihydrate

CAS No.	149394-66-1	Cat. No.	BCP07716
Name	Cidofovir dihydrate
Synonyms	Cidofovir hydrate (1:2);Gs-0504;HPMPC dihydrate; (S)-HPMPC dihydrate;
Formula	C8H14N3O6P.2(H2O)	M. Wt	315.22

Description	Cidofovir dihydrate is the dihydrate of the anhydrous form of cidofovir. Cidofovir is a synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses.
Pathways	Microbiology/Virology Cell Cycle/DNA Damage
Targets	DNA/RNA Synthesis CMV

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