RR 82
| CAS No. | 1085412-37-8 | Cat. No. | BCP07688 |
| Name | RR 82 | ||
| Synonyms | RR-82;RR 82;Pyridostatin; | ||
| Formula | C31H32N8O5 | M. Wt | 596.64 |
| Description | The increased mechanical stability of pyridostatin-bound G-quadruplex permits the determination of a dissociation constant K(d) of 490 ± 80 nM. The free-energy change of binding obtained from a Hess-like process provides an identical K(d) for pyridostatin and a K(d) of 42 ± 3 uM for a weaker ligand RR110. Pyridostatin reduced SRC protein abundance and SRC-dependent cellular motility in human breast cancer cells, validating SRC as a target of this drug. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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