Rucaparib

CAS No.	283173-50-2	Cat. No.	BCP07633
Name	Rucaparib
Synonyms	AG014699; PF-01367338;AG-014699; PF01367338;AG 014699; PF 01367338;Rucaparib free base; AG-14447; AG 14447; AG14447; Rubraca;
Formula	C19H18FN3O	M. Wt	323.37

Description	Rucaparib is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	PARP

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