西司他丁
| CAS号 | 82009-34-5 | 货号 | BCP21135 |
| 中文名 | 西司他丁 | ||
| 英文名 | Cilastatin | ||
| 中文别名 | 西司他汀;西斯他汀;西拉司丁; | ||
| 英文别名 | MK 0791; MK 791; MK-791; MK0791; MK791; MK 0791; | ||
| 分子式 | C16H26N2O5S | 分子量 | 358.45 |
| 生物活性 | Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Leukotriene Receptor | ||
结构式
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