Oprozomib
| CAS号 | 935888-69-0 | 货号 | BCP07603 |
| 中文名 | Oprozomib | ||
| 英文名 | Oprozomib | ||
| 中文别名 | |||
| 英文别名 | ONX 0912; PR 047; ONX-0912; PR-047; ONX0912; PR047; | ||
| 分子式 | C25H32N4O7S | 分子量 | 532.61 |
| 生物活性 | ONX-0912 (as known as oprozomib), discovered during a medicinal chemistry effort using tripeptide epoxyketones, is an orally bio-available and potent proteasome inhibitor that inhibits growth and induces apoptosis in bortezomib resistant multiple myeloma (MM) cells. Although ONX-0912, an analog of carfilzomib, is structurally distinct from bortezomib, it possesses the same ability as bortezomib to predominantly inhibit chymotrypsin-like activity of the proteasome. ONX-0912 exhibits significant a | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Proteasome | ||
结构式
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