LDN-57444
CAS No. | 668467-91-2 | Cat. No. | BCP07570 |
Name | LDN-57444 | ||
Synonyms | LDN 57444; LDN57444; | ||
Formula | C17H11Cl3N2O3 | M. Wt | 397.64 |
Description | Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo. | ||
Pathways | Cell Cycle/DNA Damage | ||
Targets | DUB |
Structure
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