LDN-57444

  • Chemical Properties
CAS No. 668467-91-2 Cat. No. BCP07570
Name LDN-57444
Synonyms LDN 57444; LDN57444;
Formula C17H11Cl3N2O3 M. Wt 397.64
  • Biological Activity
Description Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.
Pathways Cell Cycle/DNA Damage 
Targets DUB 

Structure

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