AZD7545

Chemical Properties

CAS No.	252017-04-2	Cat. No.	BCP07524
Name	AZD7545
Synonyms	AZD 7545; AZ-7545;
Formula	C19H18ClF3N2O5S	M. Wt	478.87

Biological Activity

Description	AZD7545 is a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively. IC50 Value: 36.8 nM (PDHK1); 6.4 nM (PDHK2) [1] Target: PDHK in vitro: The IC50 values for inhibition of PDHK2 and PDHK1 by AZD7545 were 6.4 ± 2.2 nM (n = 6) and 36.8 ± 18 nM (n = 3) respectively. Other compounds in this series inhibited both PDHK1 and PDHK2 and a consistent trend of reduced potency (5-15-fold) towards PDHK1, as compared with PDHK2,

Description

AZD7545 is a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively. IC50 Value: 36.8 nM (PDHK1); 6.4 nM (PDHK2) [1] Target: PDHK in vitro: The IC50 values for inhibition of PDHK2 and PDHK1 by AZD7545 were 6.4 ± 2.2 nM (n = 6) and 36.8 ± 18 nM (n = 3) respectively. Other compounds in this series inhibited both PDHK1 and PDHK2 and a consistent trend of reduced potency (5-15-fold) towards PDHK1, as compared with PDHK2,

Structure

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