Simeprevir

CAS No.	923604-59-5	Cat. No.	BCP07504
Name	Simeprevir
Synonyms	TMC435350; TMC435; TMC-435350;TMC-435;TMC 435;TMC 435350;TMC435350;Olysio;
Formula	C38H47N5O7S2	M. Wt	749.94

Description	Simeprevir is an orally bioavailable inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with activity against HCV genotype 1. Upon administration, simeprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of hepatocellular carcinoma (HCC).
Pathways	Protease/Metabolic Enzyme Microbiology/Virology
Targets	HCV Protease HCV

Different Interaction Profiles of Direct-Acting Anti-Hepatitis C Virus Agents with Human Organic Anion Transporting Polypeptides Publications Citing of Biochempartner's Simeprevir(CAS:923604-59-5)

Publications Citing of Biochempartner's Simeprevir(CAS:923604-59-5)

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