5-Azacytidine

CAS No.	320-67-2	Cat. No.	BCP07496
Name	5-Azacytidine
Synonyms	U18496; U-18496; U 18496;Ladakamycin; 5-AzaC; Azacitidine;
Formula	C8H12N4O5	M. Wt	244.2

Description	5-Azacytidine is a pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	DNA Methyltransferase Antimetabolite

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