Tamibarotene
| CAS No. | 94497-51-5 | Cat. No. | BCP07492 |
| Name | Tamibarotene | ||
| Synonyms | AM 80; AM-80; AM80; | ||
| Formula | C22H25NO3 | M. Wt | 351.44 |
| Description | Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | RAR/RXR | ||
Structure
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