Nafoxidine HCl
| CAS No. | 1847-63-8 | Cat. No. | BCP07493 |
| Name | Nafoxidine HCl | ||
| Synonyms | CP-5600; CP5600; CP 5600; PNU-0011100; PNU 0011100; PNU0011100; | ||
| Formula | C29H32ClNO2 | M. Wt | 462.02 |
| Description | Nafoxidine, also known as PNU-0011100 and CP-5600, is a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Hormone Pathay | ||
| Targets | Estrogen Receptor VEGFR | ||
Structure
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