Cilengitide

  • Chemical Properties
CAS No. 188968-51-6 Cat. No. BCP07359
Name Cilengitide
Synonyms EMD121974;EMD 121974;EMD-121974;NSC-707544;NSC 707544;NSC707544;
Formula C27H40N8O7 M. Wt 588.66
  • Biological Activity
Description Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets Integrin 

Structure

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