Talampanel

  • Chemical Properties
CAS No. 161832-65-1 Cat. No. BCP07340
Name Talampanel
Synonyms LY300164; LY 300164; LY-300164; GYKI53773; Gyki 53405; Gyki-53405; LY293606; LY-293606; LY 293606;
Formula C19H19N3O3 M. Wt 337.37
  • Biological Activity
Description Talampanel, also known as LY300164 and GYKI-53773, is a glutamate receptor inhibitor with anti-seizure activity. Talampanel is also an orally active, potent and selective AMPA-receptor antagonist, and can noncompetitively bind to the AMPA subtype of glutamate excitatory amino acid receptors and may inhibit the growth of gliomas by interfering with neurotransmitters involved in brain tumor growth. This agent may also protect against traumatic brain injury. Talampanel (GYKI 53405) is being investigated for the treatment of epilepsy, malignant gliomas and amyotrophic lateral sclerosis (ALS). As of May 2010, results from the trial for ALS have been found negative.
Pathways Ion Channel/Membrane Transporter 
Targets AMPA/NMDA 

Structure

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