Fotemustine

Description	Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. Fotemustine produces improved response rates and but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067). There was also toxicity prevalence in fotemustine arm. The main toxicity was grade 3 to 4 neutropenia (51% with fotemustine v 5% with DTIC) and thrombocytopenia (43% v 6%, respectively).
Pathways	Cell Cycle/DNA Damage
Targets	DNA Alkylator/Crosslinker

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