Nicotinamide
| CAS No. | 98-92-0 | Cat. No. | BCP07322 |
| Name | Nicotinamide | ||
| Synonyms | Niacinamide;Nicotinic acid amide;Vitamin B3; Vitamin PP; | ||
| Formula | C6H6N2O | M. Wt | 122.12 |
| Description | Nicotinamide, also known as niacinamide and nicotinic acid amide, is the amide of nicotinic acid (vitamin B3 / niacin).Thus nicotinamide does not reduce cholesterol or cause flushing,although nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. Studies show that nicotinamide has anxiolytic (anti-anxiety) properties. It may work in a way similar to benzodiazepines.It is an activator of sirtuins (but inhibits at higher doses) and has been reported to restore cognition in Alzheimer's disease transgenic mice.Nicotinamide can prevent apoptosis (programmed cell death) in cells exposed to agents that induce oxidative stress.Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | PARP | ||
Structure
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