Gemcitabine elaidate

CAS No.	210829-30-4	Cat. No.	BCP07317
Name	Gemcitabine elaidate
Synonyms	CO-101; CP-4126; CO 101; CP 4126; CO101; CP4126; Gemcitabine 5'-elaidate;
Formula	C27H43F2N3O5	M. Wt	527.64

Description	Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide po
Pathways	Cell Cycle/DNA Damage
Targets	DNA/RNA Synthesis Antimetabolite

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