Rotenone
| CAS No. | 83-79-4 | Cat. No. | BCP07278 |
| Name | Rotenone | ||
| Synonyms | Cube root; bCube-Pulver; Ronone; HSDB 1762; Ro-KO; | ||
| Formula | C23H22O6 | M. Wt | 394.42 |
| Description | Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. which specifically inhibits NAD-linked substrate oxidation of NADH dehydrogenase with an EC50=10 pmol/mg. It is known that this interference of the electron transport chain occurs from complex I to ubiquinone, similarly to amytal. Studies indicate that Rotenone inhibits mammalian cell proliferation, via suppressing microtubule assembly by binding to tubulin. Rotenone can inhibit the effects of N-methyl-4-phenylpyridinium on mitochondrial swelling and cytochrome c release. Rotenone is an inhibitor of NDUFS. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Mitochondrial Metabolism | ||
Structure
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