鱼滕酮

  • 化学数据
CAS号 83-79-4 货号 BCP07278
中文名 鱼滕酮
英文名 Rotenone
中文别名
英文别名 Cube root; bCube-Pulver; Ronone; HSDB 1762; Ro-KO;
分子式 C23H22O6 分子量 394.42
  • 用途
生物活性 Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. which specifically inhibits NAD-linked substrate oxidation of NADH dehydrogenase with an EC50=10 pmol/mg. It is known that this interference of the electron transport chain occurs from complex I to ubiquinone, similarly to amytal. Studies indicate that Rotenone inhibits mammalian cell proliferation, via suppressing microtubule assembly by binding to tubulin. Rotenone can inhibit the effects of N-methyl-4-phenylpyridinium on mitochondrial swelling and cytochrome c release. Rotenone is an inhibitor of NDUFS.
信号通路 Protease/Metabolic Enzyme 
靶 点 Mitochondrial Metabolism 

结构式

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