BAY 11-7085
| CAS No. | 196309-76-9 | Cat. No. | BCP07274 |
| Name | BAY 11-7085 | ||
| Synonyms | BAY 11-7083;BAY-11-7083;Bay-11-7085; Bay11-7085; Bay 117085; Bay-117085; Bay117085; | ||
| Formula | C13H15NO2S | M. Wt | 249.33 |
| Description | BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. [1] BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel.Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells. | ||
| Pathways | NFκB | ||
| Targets | NF κB | ||
Structure
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