INNO206

CAS No.	1361644-26-9	Cat. No.	BCP07265
Name	INNO206
Synonyms	DOXO-EMCH； EMCH-Doxo; EMCH-doxorubicin;INNO-206;INNO 206; Aldoxorubicin;
Formula	C37H42N4O13	M. Wt	750.75

Description	Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.
Pathways	Cell Cycle/DNA Damage Others Pathway
Targets	Topoisomerase ADC Related

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